HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF BIOGENIC-AMINES IN BIOLOGICAL-MATERIALS AS ORTHO-PHTHALALDEHYDE DERIVATIVES

被引：65

作者：

DAVIS, TP

GEHRKE, CW

CUNNINGHAM, TD

KUO, KC

GERHARDT, KO

JOHNSON, HD

WILLIAMS, CH

机构：

[1] UNIV MISSOURI, DEPT BIOCHEM, EXPT STN CHEM LABS, COLUMBIA, MO 65211 USA

[2] UNIV MISSOURI, PHYSIOL AREA, COLUMBIA, MO 65211 USA

[3] UNIV MISSOURI, DEPT DAIRY HUSB, COLUMBIA, MO 65211 USA

[4] UNIV MISSOURI, SINCLAIR COMPARAT MED RES FARM, COLUMBIA, MO 65211 USA

来源：

JOURNAL OF CHROMATOGRAPHY | 1979年 / 162卷 / 03期

关键词：

D O I：

10.1016/S0378-4347(00)81516-9

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A remarkably sensitive, simple and selective reversed-phase high-performance liquid chromatographic (HPLC) method has been developed, allowing, for the first time, the direct measurement of histamine, norepinephrine, octopamine, normetanephrine, dopamine, serotonin and tyramine in a single sample of plasma (2 ml), tissue (0.2 g), or urine. The biogenic amines were modified by pre-column derivatization with o-phthalaldehyde which stabilizes the molecules, aids in extraction, and improves HPLC detection at the nanogram level. To minimize losses during the sampling procedure a careful collection procedure was designed. © 1979.

引用

页码：293 / 310

页数：18

共 23 条

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