ALZHEIMER PATIENTS AND DOWN PATIENTS - ABNORMAL PRESYNAPTIC TERMINALS ARE RELATED TO CEREBRAL PREAMYLOID DEPOSITS

被引：52

作者：

BUGIANI, O

GIACCONE, G

VERGA, L

POLLO, B

GHETTI, B

FRANGIONE, B

TAGLIAVINI, F

机构：

[1] INDIANA UNIV,SCH MED,INDIANAPOLIS,IN 46202

[2] NYU,SCH MED,NEW YORK,NY 10003

来源：

NEUROSCIENCE LETTERS | 1990年 / 119卷 / 01期

关键词：

Alzheimer's desease; Amyloid; Down syndrome; Synapse;

D O I：

10.1016/0304-3940(90)90754-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In Alzheimer's disease, in Down syndrome and in normal aging, scattered deposits of amyloid fibril precursors occur in both cerebral cortex and subcortical grey structures. Within such preamyloid deposits, no degenerating neurites with paired helical filaments have ever been observed. This study, carried out on brains from Alzheimer patients and Down patients, reports on the relationship between preamyloid deposits and neuritic changes. These changes were represented by presynaptic terminal swellings immunolabeled by antisynaptophysin and antiubiquitin antibodies, not by Alz50. These findings support the view that the deposition of amyloid fibril precursors in the neuropil is closely related to presynaptic terminals, although whether the former precedes or follows the development of presynaptic terminal changes is still undetermined. © 1990.

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页码：56 / 59

页数：4

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