XANTHINE-OXIDASE LEVELS IN HUMAN BRAIN-TUMORS

被引：62

作者：

KOKOGLU, E ^{[1
]}

BELCE, A ^{[1
]}

OZYURT, E ^{[1
]}

TEPELER, Z ^{[1
]}

机构：

[1] CERRAHPASA MED FAC, DEPT NEUROSURG, ISTANBUL, TURKEY

来源：

CANCER LETTERS | 1990年 / 50卷 / 03期

关键词：

brain tissue; cancer; xanthine oxidase;

D O I：

10.1016/0304-3835(90)90262-V

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Xanthine oxidase is most recognized for its role as the rate-limiting enzyme in nucleic acid degradation through which all purines are channelled for terminal oxidation. The enzyme serves as a source of oxygen-derived free radicals which induce both cellular injury and edema as well as changes in vascular permeability. In the study we compared xanthine oxidase levels of human brain tumors with normal brain tissues. Statistical evaluation of our results shows significantly higher xanthine oxidase levels in tumoral brain tissues. However, xanthine oxidase has not any significance for the differentiation of tumor types among each others. The oncotypes studied were meningioma and astrocytoma. © 1990.

引用

页码：179 / 181

页数：3

共 11 条

[1] BRAIN INJURY, EDEMA, AND VASCULAR-PERMEABILITY CHANGES INDUCED BY OXYGEN-DERIVED FREE-RADICALS [J].