INTERLEUKIN-4 BLOCKS PARATHYROID HORMONE-RELATED PROTEIN-INDUCED HYPERCALCEMIA INVIVO

被引：14

作者：

NAGASAKI, K

YAMAGUCHI, K

WATANABE, K

ETO, S

ABE, K

机构：

[1] NATL CANC CTR, RES INST,DIV GROWTH FACTOR,TSUKIJI 5-1-1,CHUO KU, TOKYO 104, JAPAN

[2] UNIV OCCUPAT & ENVIRONM HLTH, SCH MED, DEPT INTERNAL MED 1, KITAKYUSHU, FUKUOKA 807, JAPAN

[3] NATL MATSUDO HOSP, CHIBA, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 178卷 / 02期

基金：

日本科学技术振兴机构;

关键词：

D O I：

10.1016/0006-291X(91)90163-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin (IL)-4 inhibits bone resorption. In the present study, the effect of IL-4 on hypercalcemia in nude mice under two experimental conditions was assessed. IL-4 inhibited plasma calcium elevation induced by parathyroid hormone-related protein (PTHrP) infusion. In hypercalcemic nude mice bearing PTHrP-producing tumors, IL-4 lowered plasma calcium levels to almost the normal range. These results indicate that IL-4 blocks PTHrP-induced hypercalcemia in vivo. © 1991.

引用

页码：694 / 698

页数：5

共 15 条

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