MEASUREMENT OF CEREBRAL MONOAMINE OXIDASE-B ACTIVITY USING L-[C-11]DEPRENYL AND DYNAMIC POSITRON EMISSION TOMOGRAPHY

被引：60

作者：

LAMMERTSMA, AA ^{[1
]}

BENCH, CJ ^{[1
]}

PRICE, GW ^{[1
]}

CREMER, JE ^{[1
]}

LUTHRA, SK ^{[1
]}

TURTON, D ^{[1
]}

WOOD, ND ^{[1
]}

FRACKOWIAK, RSJ ^{[1
]}

机构：

[1] ROCHE PROD LTD,CLIN PHARMACOL UNIT,WELWYN GARDEN CIT AL7 3AY,HERTS,ENGLAND

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 1991年 / 11卷 / 04期

关键词：

MONOAMINE OXIDASE TYPE-B; L-[C-11]DEPRENYL; METABOLITES; TRACER KINETIC MODELING; POSITRON EMISSION TOMOGRAPHY; RO-19-6327;

D O I：

10.1038/jcbfm.1991.103

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A tracer kinetic procedure was developed for the measurement of monoamine oxidase type B (MAO-B) activity using L-[C-11]deprenyl and positron emission tomography (PET). The kinetic model consisted of two tissue compartments with irreversible binding to the second compartment (three rate constants). In addition, a blood volume component was included. Special attention was given to the accurate measurement of the plasma and whole blood input functions. The method was applied to the measurement of the dose-response curve of a reversible MAO-B inhibitor (Ro 19-6327). From the results, it followed that the rate constant for irreversible binding (k3) appeared to be a better index of MAO-B activity than the net influx constant K(i). Furthermore, regional analysis demonstrated that K(i), but not k3, was flow dependent. This implies that full kinetic analysis is required for an accurate assessment of MAO-B activity.

引用

页码：545 / 556

页数：12

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