THE KA-2 SUBUNIT OF EXCITATORY AMINO-ACID RECEPTORS SHOWS WIDESPREAD EXPRESSION IN BRAIN AND FORMS ION CHANNELS WITH DISTANTLY RELATED SUBUNITS

被引：493

作者：

HERB, A ^{[1
]}

BURNASHEV, N ^{[1
]}

WERNER, P ^{[1
]}

SAKMANN, B ^{[1
]}

WISDEN, W ^{[1
]}

SEEBURG, PH ^{[1
]}

机构：

[1] MAX PLANCK INST MED RES, ZELLPHYSIOL ABT, W-6900 HEIDELBERG 1, GERMANY

来源：

NEURON | 1992年 / 8卷 / 04期

关键词：

D O I：

10.1016/0896-6273(92)90098-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A new ionotropic glutamate receptor subunit termed KA-2, cloned from rat brain cDNA, exhibits high affinity for [H-3]kainate (K(D) almost-equal-to 15 nM). KA-2 mRNA is widely expressed in embryonic and adult brain. Homomeric KA-2 expression does not generate agonist-sensitive channels, but currents are observed when KA-2 is coexpressed with GluR5 or GluR6 subunits. Specifically, coexpression of GluR5(R) and KA-2 produces channel activity, whereas homomeric expression of either subunit does not. Currents through heteromeric GluR5(Q)/KA-2 channels show more rapid desensitization and different current-voltage relations when compared with GluR5(Q) currents. GluR6/KA-2 channels are gated by AMPA, which fails to gate homomeric GluR6 receptor channels. These results suggest possible in vivo partnership relations for high affinity kainate receptors.

引用

页码：775 / 785

页数：11

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