CYSTIC-FIBROSIS GENE-THERAPY

被引：24

作者：

COLLEDGE, WH ^{[1
]}

机构：

[1] UNIV CAMBRIDGE, DEPT GENET, CAMBRIDGE CB2 1QR, CAMBS, ENGLAND

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1994年 / 4卷 / 03期

关键词：

D O I：

10.1016/0959-437X(94)90037-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A variety of cystic fibrosis gene therapy approaches based on viral (adenovirus, retrovirus, and adeno-associated virus) and non-viral (liposomes and receptor-mediated endocytosis) routes are currently being assessed for safety and efficacy. Of these, the trials involving liposomal and adenoviral vectors are the most advanced, as both have been shown to correct the cystic fibrosis Cl- conductance defect in vivo.

引用

页码：466 / 471

页数：6

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