THE INVIVO EFFECT OF SODIUM-POTASSIUM CITRATE ON THE CRYSTAL-GROWTH RATE OF CALCIUM-OXALATE AND OTHER PARAMETERS IN HUMAN URINE

被引：5

作者：

ACHILLES, W

SCHULZE, D

SCHALK, C

RODECK, G

机构：

[1] Department of Urology, Clinical Research, University Clinic Marburg, Marburg/Lahn

来源：

UROLOGICAL RESEARCH | 1990年 / 18卷 / 01期

关键词：

Alkali citrate; Calcium oxalate; Crystal growth; Human urine; Prophylactic treatment; Urolithiasis;

D O I：

10.1007/BF00294572

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

In this study, an efficient microtechnique (gel crystallization method) was used to investigate the in-vivo effect of sodium-potassium citrate on the crystal growth rate of calcium oxalate (Vcr) in human urine samples of 6 healthy volunteers. With a daily dose of 3x11 mmol of alkali citrate, Vcr decreased by 70%. This could have been due to the decrease of calcium excretion, which caused 50-60% of the total change, and to the increase of citrate and pH, each contributing about 20-25% to the decline of Vcr. The findings explain the clinical advantages of alkali citrates in the prevention of recurrent calcium oxalate stone formation. © 1990 Springer-Verlag.

引用

页码：1 / 6

页数：6

共 14 条

[1]

ACHILLES W, 1988, UROL RES, V16, P174

[2]

Achilles W, 1987, Contrib Nephrol, V58, P59

[3]

ACHILLES W, 1988, UROL RES, V16, P218

[4]

ACHILLES W, 1988, CRYSTALLIZATION RENA, P63

[5]

ACHILLES W, 1987, FORTSCHR UROL NEPHRO, V26, P11

[6]

ACHILLES W, 1985, UROLITHIASIS RELATED, P777

[7]

ACHILLES W, 1985, FORTSCHR UROL NEPHRO, V23, P252

[8]

ACHILLES W, 1985, FORTSCHR UROL NEPHRO, V23, P341

[9]

BUTZ M, 1988, CRYSTALLIZATION RENA, P159

[10]

HESSE A, 1985, FORTSCHR UROL NEPHRO, V23, P56

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