LACK OF ENHANCED PURINE BIOSYNTHESIS IN HGPRT- AND LESCH-NYHAN CELLS

被引：2

作者：

TAYLOR, MW

TOKITO, M

GUPTA, KC

机构：

来源：

HUMAN HEREDITY | 1979年 / 29卷 / 03期

关键词：

D O I：

10.1159/000153039

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The rate of de novo purine biosynthesis was measured in a series of hypoxanthine guanine phosphoribosyl transferase deficient (HGPRT-) cells from a variety of sources, including human Lesch-Nyhan cells. Under optimum growth conditions, no enhanced purine biosynthesis was detected (in contrast to previous reports). An 'elevated' level of de novo purine biosynthesis could be detected in mutants following starvation for glutamine. However, this was the result of depression of purine biosynthesis in normal cells, with a resulting artifactual overproduction in mutants.

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页码：187 / 192

页数：6

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