DEGENERATION OF THE NIGRAL DOPAMINE NEURONS AFTER 6-HYDROXYDOPAMINE INJECTION INTO THE RAT STRIATUM

被引：82

作者：

ICHITANI, Y

OKAMURA, H

MATSUMOTO, Y

NAGATSU, I

IBATA, Y

机构：

[1] KYOTO PREFECTURAL UNIV MED, DEPT ANAT, KAMIKYO KU, KYOTO 602, JAPAN

[2] KYOTO PREFECTURAL UNIV MED, DEPT PSYCHIAT, KAMIKYO KU, KYOTO 602, JAPAN

[3] FUJITA GAKUEN HLTH UNIV, SCH MED, AICHI, JAPAN

来源：

BRAIN RESEARCH | 1991年 / 549卷 / 02期

关键词：

6-HYDROXYDOPAMINE; NIGROSTRIATAL DOPAMINE SYSTEM; DEGENERATION; IMMUNOCYTOCHEMISTRY; RAT;

D O I：

10.1016/0006-8993(91)90481-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

6-Hydroxydopamine (6-OHDA) was injected into the rat striatum unilaterally. After 2-4 weeks, a marked decrease in the number of tyrosine hydroxylase-immunoreactive neuronal perikarya and dendrites was observed in the substantia nigra (SN) ipsilateral to the injection. Nissl staining showed a severe cell loss in the same region and electron microscopy revealed neuronal perikarya under degenerating process in the SN. The results showed a retrograde cytotoxic effect of 6-OHDA from the striatal terminals to their dopaminergic neuronal perikarya in the SN, and suggest the possibility that the striatum may be a primary locus in the degeneration process in Parkinson's disease.

引用

页码：350 / 353

页数：4

共 18 条

[1] FURTHER EVIDENCE FOR PRESENCE OF NIGRO-NEOSTRIATAL DOPAMINE NEURONS IN RAT [J].