SERUM IGA ANTIBODIES AGAINST PSEUDOMONAS-AERUGINOSA IN CYSTIC-FIBROSIS

被引:39
作者
BRETT, MM [1 ]
GHONEIM, ATM [1 ]
LITTLEWOOD, JM [1 ]
机构
[1] ST JAMES UNIV HOSP, DEPT MICROBIOL, LEEDS LS9 7TF, W YORKSHIRE, ENGLAND
关键词
D O I
10.1136/adc.65.3.259
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Serum IgA antibodies to Pseudomonas aeruginosa cell surface antigens were estimated by ELISA. Titres in patients with and without cystic fibrosis and with no pseudomonal infection were low (<105 to <261). Titres in patients with cystic fibrosis who were chronically infected with P aeruginosa were very high (1200-163000), and patients who grew the organism intermittently had intermediate titres. Longitudinal studies suggested increasing tissue invasion or involvement of the lower respiratory tract, or both, with increasing time of infection and identified patients with a good prognosis after the onset of pseudomonal infection. Detection of an increased serum IgA titre can give an earlier indication than measurement of the serum IgG titre of the presence of P aeruginosa in the respiratory tract in a proportion of patients. IgA measurement seems to be better than IgG measurement at predicting the reappearance of P aeruginosa after apparent eradication of early infection. These results suggest that this assay may be a valuable additional indicator of the presence of P aeruginosa at the beginning of infection, and of the reappearance of the organism after treatment in the early stages of infection.
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页码:259 / 263
页数:5
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