GEOGRAPHIC DIVERSITY OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 - SEROLOGIC REACTIVITY TO ENV EPITOPES AND RELATIONSHIP TO NEUTRALIZATION

被引：52

作者：

CHEINGSONGPOPOV, R

CALLOW, D

BEDDOWS, S

SHAUNAK, S

WASI, C

KALEEBU, P

GILKS, C

PETRASCU, IV

GARAEV, MM

WATTS, DM

CONSTANTINE, NT

WEBER, JN

机构：

[1] ST MARYS HOSP,SCH MED,DEPT GENITOURINARY MED,JEFFERISS RES WING,PRAED ST,LONDON W2 1NY,ENGLAND

[2] SIRIRAJ HOSP,FAC MED,DEPT MICROBIOL,DIV VIROL,WHO COLLABORATING CTR AIDS,BANGKOK 7,THAILAND

[3] UGANDA VIRUS RES INST,ENTEBBE,UGANDA

[4] KENYA GOVT MED RES CTR,WELLCOME TRUST RES LABS,NAIROBI,KENYA

[5] ROMANIAN AIDS ASSOC,BUCHAREST,ROMANIA

[6] DI IVANOVSKII VIROL INST,DEPT MOLEC BIOL,MOSCOW,USSR

[7] USN,MED RES UNIT 3,DIV VIROL,WHO AIDS COLLABORATING CTR,CAIRO,EGYPT

[8] UNIV MARYLAND,SCH MED,DEPT PATHOL,BALTIMORE,MD 21201

来源：

JOURNAL OF INFECTIOUS DISEASES | 1992年 / 165卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1093/infdis/165.2.256

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The antibody recognition of the major neutralization epitopes of human immunodeficiency virus type 1 (HIV-1) in 829 HIV-1-seropositive subjects from North America (106), Europe (241), Africa (342), and Asia (100) was investigated. Peptides derived from diverse published V3 loop sequences were used as antigen, and serum reactivity was detected by sensitive ELISAs. Antibody binding to peptides derived from the V3 loop sequence of HIV-1 isolates varies considerably depending on the geographic origin of the antibody and is associated with neutralization titer against homologous isolates. Serotype reactivity to pepides may be a simple and rapid approach to investigation of HIV-1 env diversity worldwide and may assist the choice of immunogen for development of future AIDS vaccines.

引用

页码：256 / 261

页数：6

共 20 条

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