COMPARISON OF LIGANDS OF DIFFERING DENTICITY AND BASICITY FOR THE INVIVO CHELATION OF ALUMINUM AND GALLIUM

被引：81

作者：

CLEVETTE, DJ

ORVIG, C

机构：

[1] Department of Chemistry, University of British Columbia, Vancouver, BC V6T 1Y6

来源：

POLYHEDRON | 1990年 / 9卷 / 2-3期

关键词：

D O I：

10.1016/S0277-5387(00)80564-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Twenty-eight chelating ligands for aluminium, gallium and indium have been evaluated as binders of the M3+ ions in a simple human blood plasma model. Effective formation constants (at pH 7.4) and values of pM (-log[M3+]) were not found to be convenient tools for the comparison of all ligands under certain conditions. Speciation modelling allowed a direct comparison amongst ligands of the binding efficacy towards these metal ions under blood plasma conditions (50 μM transferrin sites, 0.1 M citrate, pH 7.4, 25°C). Applications of speciation computer modelling to animal studies are also discussed. © 1990.

引用

页码：151 / 161

页数：11

共 44 条

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