LINKAGE OF A GENE FOR NEURAL CELL-ADHESION MOLECULE, L1 (CAML1) TO THE RSVP REGION OF THE MOUSE X-CHROMOSOME

被引：10

作者：

CHAPMAN, VM

KEITZ, BT

STEPHENSON, DA

MULLINS, LJ

MOOS, M

SCHACHNER, M

机构：

[1] UNIV HEIDELBERG,DEPT PHARMACOL,W-6900 HEIDELBERG,GERMANY

[2] UNIV HEIDELBERG,DEPT NEUROBIOL,W-6900 HEIDELBERG,GERMANY

来源：

GENOMICS | 1990年 / 8卷 / 01期

关键词：

D O I：

10.1016/0888-7543(90)90232-J

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

L1 is a glycoprotein with an apparent molecular weight of 200 kDa in the developing fetus and adult central nervous system. In the peripheral nervous system, it has a molecular weight of 230 kDa. The L1 protein appears to be encoded by a single gene that has been located on the human X chromosome by in situ hybridization. In this paper we describe restriction variation in genomic DNA Southern analysis between Mus species for the K13 cDNA probe for the L1 neural cell adhesion molecule. We have designated the locus described by this variation as cell adhesion molecule L1, CamL1. The X chromosome linkage and the relative position on the X chromosome coincident with the genes Rsvp/G6pd/Cf-8 were defined in backcross matings involving M. spretus and M. musculus. © 1990.

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页码：113 / 118

页数：6

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