AGE-DEPENDENT DIFFERENCES IN THE ANTICONVULSANT EFFECTS OF 2-AMINO-7-PHOSPHONO-HEPTANOIC ACID OR KETAMINE INFUSIONS INTO THE SUBSTANTIA-NIGRA OF RATS

被引：23

作者：

WURPEL, JND

SPERBER, EF

MOSHE, SL

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROL,BRONX,NY 10461

[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PEDIAT,BRONX,NY 10461

[3] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROSCI,BRONX,NY 10461

来源：

EPILEPSIA | 1992年 / 33卷 / 03期

关键词：

NEUROLOGIC MODEL; CONVULSIONS; SUBSTANTIA-NIGRA; KETAMINE; 2-AMINO-7-PHOSPHO-HEPATANOIC ACID;

D O I：

10.1111/j.1528-1157.1992.tb01688.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Infusions of 2-amino-7-phosphonoheptanoic acid (AP7) or ketamine into the substantia nigra pars reticulata (SNPR) of adult rats increase the latency of onset to seizures induced by the convulsant ether flurothyl. Nigral infusions of AP7 or ketamine in concentrations up to 10 times greater than the adult dose are ineffective in 16-day-old rats. These results suggest that differences in seizure susceptibility between adult and immature rats may be related to differences in excitatory amino acid neurotransmission in the SN.

引用

页码：439 / 443

页数：5

共 30 条

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