S-2-(2,4-DINITROPHENYL)ETHYL-L-CYSTEINE - A NEW DERIVATIVE FOR SOLID-PHASE PEPTIDE-SYNTHESIS

被引：8

作者：

ROYO, M

GARCIAECHEVERRIA, C

GIRALT, E

ERITJA, R

ALBERICIO, F

机构：

[1] CSIC,CID,DEPT MOLEC GENET,JORDI GIRONA 18-26,E-08034 BARCELONA,SPAIN

[2] UNIV BARCELONA,DEPT ORGAN CHEM,E-08028 BARCELONA,SPAIN

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 17期

关键词：

CYSTEINE-PROTECTION; DISULFIDE BRIDGES; BETA-ELIMINATION; SOLID-PHASE PEPTIDE SYNTHESIS;

D O I：

10.1016/S0040-4039(00)74220-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new acid stable protecting group for the sulfhydryl function of cysteine is described. The S-2-(2,4-dinitrophenyl)ethyl-L-cysteine derivative is fully compatible with the Boc/Bzl solid-phase peptide synthesis strategy and can be smoothly and quantitatively removed to give the free thiol or a disulfide bridge.

引用

页码：2391 / 2394

页数：4

共 20 条

[1]

ALBERICIO F, 1991, INT J PEPT PROT RES, V33, P402

[2] NEW AMINO PROTECTING GROUP REMOVABLE BY REDUCTION - CHEMISTRY OF DITHIASUCCINOYL (DTS) FUNCTION [J].