GLYCOSYLATED DERIVATIVES OF BENZOPHENONE, BENZHYDROL, AND BENZHYDRIL AS POTENTIAL VENOUS ANTITHROMBOTIC AGENTS

被引：53

作者：

BELLAMY, F

HORTON, D

MILLET, J

PICART, F

SAMRETH, S

CHAZAN, JB

机构：

[1] LAB FOURNIER SA, CTR RECH, 50 RUE DIJON, F-21121 DAIX, FRANCE

[2] OHIO STATE UNIV, DEPT CHEM, COLUMBUS, OH 43210 USA

[3] ITERG, F-75002 PARIS, FRANCE

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 36卷 / 07期

关键词：

D O I：

10.1021/jm00059a015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of glycosylated derivatives of benzophenone, benzhydrol, and benzhydril has been synthesized and evaluated for potential activity as venous antithrombotic agents. Studies on structure-activity relationships revealed that compounds having an electron-withdrawing group in the benzhydril or benzhydrol moiety, and specifically those having the beta-D-xylopyranosyl structure in the sugar moiety, were good antithrombotic agents in a rat model of venous thrombosis.

引用

页码：898 / 903

页数：6

共 40 条

[1] ANTICOAGULANT PROPERTIES OF HEPARIN FRACTIONATED BY AFFINITY CHROMATOGRAPHY ON MATRIX-BOUND ANTITHROMBIN-3 AND BY GEL-FILTRATION
ANDERSSON, LO
BARROWCLIFFE, TW
HOLMER, E
JOHNSON, EA
SIMS, GEC
[J]. THROMBOSIS RESEARCH, 1976, 9 (06) : 575 - 583
[2] [Anonymous], ORGANIC SYNTHESES CO
[3] ASTOIN J, 1980, EUR J MED CHEM, V15, P457
[4] Bochkov AF, 1979, CHEM O GLYCOSIDIC BO
[5] CARTER CJ, 1982, BLOOD, V59, P1239
[6] CREMONESI P, 1987, Drugs of the Future, V12, P45
[7] DAWES J, 1989, THROMB HAEMOSTASIS, V62, P945
[8] EICHENAUER U, 1969, NIPPON KAGAKU KAISHI, V11, P1870
[9] A MODIFIED STASIS THROMBOSIS MODEL TO STUDY THE ANTITHROMBOTIC ACTIONS OF HEPARIN AND ITS FRACTIONS
FAREED, J
WALENGA, JM
KUMAR, A
ROCK, A
[J]. SEMINARS IN THROMBOSIS AND HEMOSTASIS, 1985, 11 (02) : 155 - 175
[10] CHEMICAL AND BIOLOGICAL HETEROGENEITY IN LOW-MOLECULAR WEIGHT HEPARINS - IMPLICATIONS FOR CLINICAL USE AND STANDARDIZATION
FAREED, J
WALENGA, JM
HOPPENSTEADT, D
RACANELLI, A
COYNE, E
[J]. SEMINARS IN THROMBOSIS AND HEMOSTASIS, 1989, 15 (04) : 440 - 463

← 1 2 3 4 →