IMPROVED DELIVERY THROUGH BIOLOGICAL-MEMBRANES .8. DESIGN, SYNTHESIS, AND INVIVO TESTING OF TRUE PRODRUGS OF ASPIRIN

被引：34

作者：

LOFTSSON, T

KAMINSKI, JJ

BODOR, N

机构：

[1] UNIV FLORIDA, J HILLIS MILLER HLTH CTR, COLL PHARM, DEPT MED CHEM, GAINESVILLE, FL 32610 USA

[2] UNIV KANSAS, SCH PHARM, DEPT PHARMACEUT CHEM, LAWRENCE, KS 66045 USA

[3] INTER RES CORP, LAWRENCE, KS 66044 USA

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1981年 / 70卷 / 07期

关键词：

D O I：

10.1002/jps.2600700708

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：743 / 749

页数：7

共 35 条

[1]

ARON E, 1976, THERAPIE, V31, P247

[2] MECHANISMS OF CATALYSIS OF NUCLEOPHILIC REACTIONS OF CARBOXYLIC ACID DERIVATIVES [J].

BENDER, ML .

CHEMICAL REVIEWS, 1960, 60 (01) :53-113

[3]

COUSSE H, 1978, TRAV SOC PHARM MONTP, V38, P71

[4] GASTRIC BLEEDING AND BENORYLATE - NEW ASPIRIN [J].

CROFT, DN ;

CUDDIGAN, JH ;

SWEETLAND, C .

BMJ-BRITISH MEDICAL JOURNAL, 1972, 3 (5826) :545-+

[5]

DAVIS AF, 1978, Patent No. 1518622

[6] SALICYLATE METABOLISM IN MAN [J].

DAVISON, C .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1971, 179 (JUL6) :249-+

[7] COMPARATIVE DISPOSITION OF SULINDAC AND METABOLITES IN 5 SPECIES [J].

DUGGAN, DE ;

HOOKE, KF ;

NOLL, RM ;

HUCKER, HB ;

VANARMAN, CG .

BIOCHEMICAL PHARMACOLOGY, 1978, 27 (19) :2311-2320

[8] THE HYDROLYSIS OF ASPIRIN - A DETERMINATION OF THE THERMODYNAMIC DISSOCIATION CONSTANT AND A STUDY OF THE REACTION KINETICS BY ULTRA-VIOLET SPECTROPHOTOMETRY [J].

EDWARDS, LJ .

TRANSACTIONS OF THE FARADAY SOCIETY, 1950, 46 (09) :723-&

[9] THE HYDROLYSIS OF ASPIRIN .2. [J].

EDWARDS, LJ .

TRANSACTIONS OF THE FARADAY SOCIETY, 1952, 48 (08) :696-699

[10] INTRAMOLECULAR NUCLEOPHILIC CATALYSIS OF ESTER HYDROLYSIS BY IONIZED CARBOXYL GROUP . HYDROLYSIS OF 3,5-DINITROASPIRIN ANION [J].

FERSHT, AR ;

KIRBY, AJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1968, 90 (21) :5818-&

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