RADIATION-DOSE RATES FROM ADULT PATIENTS RECEIVING I-131 THERAPY FOR THYROTOXICOSIS

被引:54
作者
ODOHERTY, MJ
KETTLE, AG
EUSTANCE, CNP
MOUNTFORD, PJ
COAKLEY, AJ
机构
[1] Department of Nuclear Medicine, Kent and Canterbury Hospital, Canterbury, Kent
[2] Department of Nuclear Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham
关键词
D O I
10.1097/00006231-199303000-00003
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Recommendations for restricting the exposure to radiation of members of the public coming into contact with thyrotoxic patients treated with I-131 are currently based on the activity retained by the patient, and not on the doses likely to be received by such individuals. In order to examine whether these current recommendations restrict these doses to less than the current annual limit of 5 mSv, and to identify the implications of a reduction in this limit to 1 mSv, measurements were made of the dose rates at distances of 0.1, 0.5 and 1.0 m from 60 patients just before they left the nuclear medicine department. These measurements were repeated 1, 3, 6, 8 and 10 days after administration for 30 patients, and the radioactivity in samples of saliva taken on each of these days and secreted in sweat over the first 24 h were also measured. Doses were estimated for administered activities of approximately 200-600 MBq, assuming appropriate values for the times and distances spent near other individuals while travelling, at work, at home and near to young children considered in three age groups (<2, 2-5 and 5-11 years). Periods of restriction were derived which would reduce these doses to 5 or 1 mSv. For a dose limit of 5 mSv, there is no need to restrict private travel, public transport journeys can last up to 7 h, a patient can return to work immediately, but sleeping with a partner will have to be restricted even for the minimum activity of 200 MBq. For a dose limit of 1 mSv, public transport journeys should not exceed 1 h for an administered activity of 600 MBq or 3.5 h for 200 MBq, and return to work should be delayed if the administered activity exceeds 300 MBq. The periods to restrict close contact with young children in order to limit their dose to 1 mSv were verv similar to the current recommendations based on retained activity.
引用
收藏
页码:160 / 168
页数:9
相关论文
共 22 条
[1]  
Mountford P.J., Coakley A.J., Radioactive patients, Br Med J, 298, pp. 1538-1539, (1989)
[2]  
Guidance Notes for the Protection of Persons against Ionising Radiations Arising from Medical and Dental Use, (1985)
[3]  
Hilditch T.E., Connell J., Davies D.L., Watson W.S., Alexander W.D., Radiological protection guidance for radioactive patients - new data for therapeutic I131, Nucl Med Commun, 12, pp. 485-495, (1991)
[4]  
Gimlette T., Kocak R., Herbert R.G., Squire C.R., The effect of carbimazole following radioiodine therapy on radiation dose to the thyroid, Nucl Med, 20, pp. 72-75, (1981)
[5]  
Recommendations of the International Commission on Radiological Protection, Annals of the ICRP, 21, 1-3, (1990)
[6]  
Harding L.K., Mostafa A.B., Roden L., Williams N., Dose rates from patients having nuclear medicine investigations, Nucl Med Commun, 6, pp. 191-194, (1985)
[7]  
Mountford P.J., O'doherty M.J., Forge N.I., Jeffries A., Coakley A.J., Radiation dose rates from adult patients undergoing nuclear medicine investigations, Nucl Med Commun, 12, pp. 767-777, (1991)
[8]  
Mountford P.J., Estimation of close contact doses to young infants from surface dose rates on radioactive adults, Nucl Med Commun, 8, pp. 857-863, (1987)
[9]  
Rose M.R., Prescott M.C., Herman K.J., Excretion of iodine- 123-hippuran, technetium-99m-red blood cells, and technetium-99m-macroaggregated albumin into breast milk, J Nucl Med, 31, pp. 978-984, (1990)
[10]  
O'connor M.K., Cullen M.J., Malone J.F., The value of a tracer dose in predicting the kinetics of therapeutic doses of 131I in thyrotoxicosis, Br J Radiol, 52, pp. 719-726, (1979)