CLONAL HETEROGENEITY IN THE PROGENY OF HELA-CELLS WHICH SURVIVE X-IRRADIATION

被引：40

作者：

BROWN, DC ^{[1
]}

TROTT, KR ^{[1
]}

机构：

[1] UNIV LONDON ST BARTHOLOMEWS HOSP & MED COLL,DEPT RADIAT BIOL,LONDON EC1M 6BQ,ENGLAND

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 1994年 / 66卷 / 02期

关键词：

D O I：

10.1080/09553009414551051

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Clones of HeLa cells that had survived 9 Gy X-rays were investigated for plating efficiency, radiosensitivity, the proportion of giant cells, and chromosome numbers. A significant decrease in plating efficiency was observed that persisted for >20 population doublings. The reduced plating efficiency was associated with an increased proportion of giant cells in the colonies. There was pronounced clonal heterogeneity in the progeny of irradiated surviving cells with respect to plating efficiency, proportion of giant cells, and chromosome numbers. The radiosensitivity of progeny from irradiated cells did not change compared with controls.

引用

页码：151 / 155

页数：5

共 18 条

[1]

BEER JZ, 1979, ADV RADIAT BIOL, V8, P363

[2] CLONOGENICITY OF THE PROGENY OF SURVIVING CELLS AFTER IRRADIATION [J].

BORN, R ;

TROTT, KR .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1988, 53 (02) :319-330

[3] DELAYED REPRODUCTIVE DEATH IN X-IRRADIATED CHINESE-HAMSTER OVARY CELLS [J].

CHANG, WP ;

LITTLE, JB .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1991, 60 (03) :483-496

[4] DELAYED REPRODUCTIVE DEATH AS A DOMINANT PHENOTYPE IN CELL CLONES SURVIVING X-IRRADIATION [J].

CHANG, WP ;

LITTLE, JB .

CARCINOGENESIS, 1992, 13 (06) :923-928

[5] EVIDENCE THAT DNA DOUBLE-STRAND BREAKS INITIATE THE PHENOTYPE OF DELAYED REPRODUCTIVE DEATH IN CHINESE-HAMSTER OVARY CELLS [J].

CHANG, WP ;

LITTLE, JB .

RADIATION RESEARCH, 1992, 131 (01) :53-59

[6] CLONAL HETEROGENEITY IN DELAYED DECREASE OF PLATING EFFICIENCY OF IRRADIATED HELA-CELLS [J].

FITZEK, M ;

TROTT, KR .

RADIATION AND ENVIRONMENTAL BIOPHYSICS, 1993, 32 (01) :33-39

[7]

FRESHNEY I, 1987, CULTURE MAMMALIAN CE

[8] EXPRESSION OF LETHAL MUTATIONS IN PROGENY OF IRRADIATED MAMMALIAN-CELLS [J].

GORGOJO, L ;

LITTLE, JB .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1989, 55 (04) :619-630

[9]

HUG O., 1963, BIOPHYSIK, V1, P20, DOI 10.1007/BF01192565

[10] TIME-LAPSE CINEMICROGRAPHIC STUDIES OF X-IRRADIATED HELA S3 CELLS .2. CELL FUSION [J].

HURWITZ, C ;

TOLMACH, LJ .

BIOPHYSICAL JOURNAL, 1969, 9 (09) :1131-&

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