STUDIES ON MICROBIAL DEGRADATION OF CEPHALOSPORIN C DERIVATIVES .I. ROLE OF BETA-LACTAMASE AND ACYLESTERASE IN ENZYMATIC DEGRADATION OF CEPHALOSPORINS

被引：9

作者：

NISHIDA, M

YOKOTA, Y

OKUI, M

MINE, Y

MATSUBAR.T

机构：

[1] Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Osaka

来源：

JOURNAL OF ANTIBIOTICS | 1968年 / 21卷 / 03期

关键词：

D O I：

10.7164/antibiotics.21.165

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

m-Bromophenylacetamidocephalosporanic acid(m-Br-PACA) was highly degraded by a strain(No. 11)of E. coli, but less degraded by a strain(No. 33) of Staph. aureus. α-Phenylacetamidocephalosporanic acid (α-Ph-POCA) gave opposite results with these bacteria. A cephalosporin C derivative, m-Cl PACA, was degraded by acylesterase as well as by β-lactamase with E. coli No.11. © 1968, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：165 / &

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