CORTICOSTERONE REGULATION OF TRYPTOPHAN HYDROXYLASE IN MIDBRAIN OF RAT

被引：183

作者：

AZMITIA, EC

MCEWEN, BS

机构：

[1] Rockefeller University, New York

来源：

SCIENCE | 1969年 / 166卷 / 3910期

关键词：

D O I：

10.1126/science.166.3910.1274

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The tryptophan hydroxylase activity in the rat midbrain decreases after adrenalectomy and is restored by treatment with corticosterone. Cycloheximide, administered intracisternally. prevents the restoration of the enzyme activity by corticosterone. Cycloheximide administration to adrenalectomized rats results in a further decrease in the enzyme activity, an indication that the enzyme has a rapid turnover even in the absence of corticosterone.

引用

页码：1274 / &

共 23 条

[1]

AZMITIA EC, IN PRESS

[2]

BLEULER M, 1962, HANDBUCH EXPERIMENTE, V14, pCH6

[3] SPECIES DIFFERENCES IN ADRENOCORTICAL SECRETION [J].