EFFECT OF LONG-LASTING DIABETES-MELLITUS ON RAT AND HUMAN-BRAIN MONOAMINES

被引:108
作者
LACKOVIC, Z [1 ]
SALKOVIC, M [1 ]
KUCI, Z [1 ]
RELJA, M [1 ]
机构
[1] MED SCH ZAGREB, DEPT PHARMACOL & NEUROL, MOLEC NEUROPHARMACOL LAB, Zagreb, YUGOSLAVIA
关键词
Alloxan diabetes; Dopamine; Human brain post mortem; Norepinephrine; Serotonin; Streptozotocin diabetes;
D O I
10.1111/j.1471-4159.1990.tb13294.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Abstract: Experimental alloxan‐ or streptozotocin‐produced diabetes in rats was accompanied by an increase in the levels of norepinephrine, dopamine, and serotonin, whereas the contents of metabolites, i.e., 5‐hydroxyindoleacetic acid and homovanillic acid, in the whole brain gradually decreased with the duration of diabetes. Among the striatum, thalamus, and hypothalamus of alloxan diabetic rats, monoamine alterations were observed only in the hypothalamus; after 1 week an increase of norepinephrine content and after 13 weeks an increase of norepinephrine and dopamine contents were found. Tissues of 11 brain regions of 10 diabetic and 12 control patients post mortem were investigated for monoamine concentrations. Patients were all male, of similar age and interval between death and autopsy. Diabetic patients had an increase in the content of serotonin in the medial and lateral hypothalamus. The content of dopamine increased in the medial hypothalamus, putamen, and medial and lateral pallidus. In diabetic patients, the content of norepinephrine increased in the lateral pallidus and decreased in the nucleus accumbens and claustrum. Thus, it seems that diabetes mellitus in rats, as well as in humans is associated with regionally specific changes in brain monoamines. Copyright © 1990, Wiley Blackwell. All rights reserved
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页码:143 / 147
页数:5
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