EFFECT OF CERULENIN AND EXOGENOUS FATTY-ACIDS ON TRIACYLGLYCEROL ACCUMULATION IN AN INOSITOL-DEFICIENT YEAST, SACCHAROMYCES-CARLSBERGENSIS

被引：9

作者：

DAUM, G

GAMERITH, G

PALTAUF, F

机构：

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 573卷 / 02期

关键词：

(Yeast); Cerulenin; Inositol deficiency; Triacylglycerol;

D O I：

10.1016/0005-2760(79)90075-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cerulenin inhibits fatty acid synthesis in yeast; supplementation with exogenous fatty acids is required to maintain cell growth. In the presence of cerulenin and exogenous fatty acids inositol-deficient cells accumulate triacylglycerols to almost the same extent as normally grown deficient cells, indicating that increased fatty acid synthesis is not primarily responsible for triacylglycerol accumulation. © 1979.

引用

收藏

页码：413 / 415

页数：3

相关论文

共 11 条

[1] SUBSTITUTION OF CELLULAR FATTY-ACIDS IN YEAST-CELLS BY ANTIBIOTIC CERULENIN AND EXOGENOUS FATTY-ACIDS [J].

AWAYA, J ;

OHNO, T ;

OHNO, H ;

OMURA, S .

BIOCHIMICA ET BIOPHYSICA ACTA, 1975, 409 (03) :267-273

[2] LIPID-METABOLISM IN AN INOSITOL-DEFICIENT YEAST, SACCHAROMYCES-CARLSBERGENSIS - INFLUENCE OF TEMPERATURE AND ANAEROBIOSIS ON CELLULAR LIPID-COMPOSITION [J].

DAUM, G ;

GLATZ, H ;

PALTAUF, F .

BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 488 (03) :484-492

[3]

FOLCH J, 1957, J BIOL CHEM, V226, P497

[4] EFFECT OF CERULENIN ON STEROL BIOSYNTHESIS IN SACCHAROMYCES-CEREVISIAE [J].

GREENSPAN, MD ;

MACKOW, RC .

LIPIDS, 1977, 12 (09) :729-731

[5]

HAYASHI E, 1976, J BIOL CHEM, V251, P5759

[6] FLUCTUATION OF VARIOUS ENZYME-ACTIVITIES DUE TO MYOINOSITOL DEFICIENCY IN SACCHAROMYCES-CARLSBERGENSIS [J].

HAYASHI, E ;

HASEGAWA, R ;

TOMITA, T .

BIOCHIMICA ET BIOPHYSICA ACTA, 1978, 540 (02) :231-237

[7]

JOHNSTON J M, 1970, Biochimica et Biophysica Acta, V218, P431, DOI 10.1016/0005-2760(70)90006-8

[8] EFFECTS OF MESO-INOSITOL DEFICIENCY ON SOME IMPORTANT BIOLOGICAL AND CHEMICAL CHARACTERISTICS OF YEAST [J].

LEWIN, LM .

JOURNAL OF GENERAL MICROBIOLOGY, 1965, 41 (02) :215-&

[9] TARGET OF INHIBITION BY ANTI-LIPOGENIC ANTIBIOTIC CERULENIN OF STEROL SYNTHESIS IN YEAST [J].

OHNO, T ;

KESADO, T ;

AWAYA, J ;

OMURA, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1974, 57 (04) :1119-1124

[10] ANTIBIOTIC CERULENIN, A NOVEL TOOL FOR BIOCHEMISTRY AS AN INHIBITOR OF FATTY-ACID SYNTHESIS [J].

OMURA, S .

BACTERIOLOGICAL REVIEWS, 1976, 40 (03) :681-697