5-HT NEUROENDOCRINE RESPONSES DURING PSYCHOTROPIC-DRUG TREATMENT - AN INVESTIGATION OF THE EFFECTS OF LITHIUM

被引：7

作者：

COWEN, PJ ^{[1
]}

COHEN, PR ^{[1
]}

MCCANCE, SL ^{[1
]}

FRISTON, KJ ^{[1
]}

机构：

[1] LITTLEMORE HOSP,MRC,CLIN PHARMACOL UNIT,OXFORD,ENGLAND

来源：

JOURNAL OF NEUROSCIENCE METHODS | 1990年 / 34卷 / 1-3期

基金：

英国惠康基金;

关键词：

5-Hydroxytryptamine; ACTH; Growth hormone; Lithium; Prolactin;

D O I：

10.1016/0165-0270(90)90059-O

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Increasing brain 5-hydroxytryptamine (5-HT) function in humans raises plasma concentrations of prolactin, growth hormone and ACTH. Measurement of these hormonal responses provides an index of the functional activity of brain 5-HT pathways. More recent strategies have included the use of directly-acting 5-HT receptor agonists to probe the function of specific receptor subtypes; at present these studies are limited by the questionable selectivity of the agonists employed. Using 5-HT neuroendocrine testing it can be shown that lithium specifically increases the prolactin release mediated by 5-HT pathways. Further studies are needed to determine if this effect is caused by an enhanced sensitivity of post-synaptic 5-HT1A receptors. © 1990.

引用

页码：201 / 205

页数：5

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