PHENCYCLIDINE-INDUCED IPSILATERAL ROTATION IN RATS WITH UNILATERAL 6-HYDROXYDOPAMINE-INDUCED LESIONS OF THE SUBSTANTIA NIGRA

被引：64

作者：

FESSLER, RG ^{[1
]}

STURGEON, RD ^{[1
]}

MELTZER, HY ^{[1
]}

机构：

[1] UNIV CHICAGO,PRITZKER SCH MED,DEPT PSYCHIAT,CHICAGO,IL 60637

来源：

LIFE SCIENCES | 1979年 / 24卷 / 14期

关键词：

D O I：

10.1016/0024-3205(79)90147-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of phencyclidine (PCP) on rotational behavior in rats with unilateral 6-hydroxydopamine (6-OHDA)-induced lesions of the substantia nigra was examined and compared to the effects of d-amphetamine and apomorphine. PCP, like d-amphetamine, induced ipsilateral rotation indicating a presynaptic effect on dopamine (DA) neurons whereas apomorphine, a direct acting agonist, caused contralateral rotation. Pretreatment with alpha-methyparatyrosine inhibited PCP-induced rotation approximately to the same extent as it inhibited d-amphetamine-induced rotation, but did not significantly reduce apomorphine-induced contralateral turning, further indicating that PCP has a presynaptic effect on DA neurons. Anti-cholinergic effects on PCP may also contribute to the ipsilateral rotation noted. © 1979.

引用

页码：1281 / 1288

页数：8

共 19 条

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