INTERPHASE CYTOGENETICS REVEALS SOMATIC PAIRING OF CHROMOSOME-17 CENTROMERES IN NORMAL HUMAN BRAIN-TISSUE, BUT NO TRISOMY-7 OR SEX-CHROMOSOME LOSS

被引：68

作者：

ARNOLDUS, EPJ

NOORDERMEER, IA

PETERS, ACB

RAAP, AK

VANDERPLOEG, M

机构：

来源：

CYTOGENETICS AND CELL GENETICS | 1991年 / 56卷 / 3-4期

关键词：

D O I：

10.1159/000133092

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nuclei isolated from normal human brain tissue, collected from six autopsies, were hybridized with a panel of nine satellite DNA probes specific for the centromeric regions of chromosomes 1, 6, 7, 10, 11, 17, 18, and the X and Y chromosomes. The results did not confirm the recently reported trisomy 7 and loss of sex chromosomes observed in metaphases obtained from normal brain tissue after short-term cultures; however, cells of all six brains displayed somatic pairing of the chromosome 17 centromeres in approximately 50% of the nuclei.

引用

页码：214 / 216

页数：3

共 12 条

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