FUNCTIONALIZATION OF 5-METHYL-2-HALONICOTINIC ACID-DERIVATIVES

被引:5
作者
PONTICELLO, GS
BALDWIN, JJ
机构
[1] Department of Medicinal Chemistry, Merck Sharp & Dohme Research Laboratories, Pennsylvania 19486, West Point
关键词
D O I
10.1021/jo01329a022
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Methodology is described for the preparation of pyridines containing versatile functional groups in the 2, 3, and 5 positions via di and tri NBS brominations of the C-5 methyl group of 2-halonicotinic acid derivatives. Reductive dehalogenation of the 2-bromo substituent provides for a facile synthesis of unsymmetrical pyridines in which the oxidation state of the C-3 and C-5 groups can be effectively controlled. © 1979, American Chemical Society. All rights reserved.
引用
收藏
页码:2702 / 2704
页数:3
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