FUNCTIONALIZATION OF 5-METHYL-2-HALONICOTINIC ACID-DERIVATIVES

被引：5

作者：

PONTICELLO, GS

BALDWIN, JJ

机构：

[1] Department of Medicinal Chemistry, Merck Sharp & Dohme Research Laboratories, Pennsylvania 19486, West Point

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 15期

关键词：

D O I：

10.1021/jo01329a022

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Methodology is described for the preparation of pyridines containing versatile functional groups in the 2, 3, and 5 positions via di and tri NBS brominations of the C-5 methyl group of 2-halonicotinic acid derivatives. Reductive dehalogenation of the 2-bromo substituent provides for a facile synthesis of unsymmetrical pyridines in which the oxidation state of the C-3 and C-5 groups can be effectively controlled. © 1979, American Chemical Society. All rights reserved.

引用

页码：2702 / 2704

页数：3

共 7 条

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