REGIOSELECTIVE O-ALKYLATION OF CORTIENIC ACID AND SYNTHESIS OF A NEW CLASS OF GLUCOCORTICOIDS CONTAINING A 17-ALPHA-ALKOXY, A 17-ALPHA-(1'-ALKOXYETHYLOXY), A 17-ALPHA-ALKOXYMETHYLOXY, OR A 17-ALPHA-METHYLTHIOMETHYLOXY FUNCTION

被引：13

作者：

DRUZGALA, P ^{[1
]}

BODOR, N ^{[1
]}

机构：

[1] UNIV FLORIDA,J HILLIS MILLER HLTH CTR,CTR DRUG DISCOVERY,BOX J-497,GAINESVILLE,FL 32610

来源：

STEROIDS | 1991年 / 56卷 / 09期

关键词：

SOFT DRUGS; STEROIDS; CORTIENIC ACID; REGIOSELECTIVE O-ALKYLATION;

D O I：

10.1016/0039-128X(91)90008-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of a new class of glucocorticoids, to be evaluated as anti-inflammatory agents with expected low systemic toxicity, is described. The new steroids possess a 17-beta-chloromethyl carboxylate function and a 17-alpha-alkoxy, a 17-alpha-(1'-alkoxyethyloxy), a 17-alpha-alkoxymethyloxy, or a 17-alpha-methylthiomethyloxy function. A 17-alpha-alkoxy function is a new feature in cortisol analogs.

引用

页码：490 / 494

页数：5

共 10 条

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