GLP-1(7-36)AMIDE-STIMULATED INSULIN-SECRETION IN RAT ISLETS IS SODIUM-DEPENDENT

被引：13

作者：

FRIDOLF, T ^{[1
]}

AHREN, B ^{[1
]}

机构：

[1] UNIV LUND, DEPT SURG, S-22362 LUND, SWEDEN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 179卷 / 01期

关键词：

D O I：

10.1016/0006-291X(91)91429-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examined the Na+-dependency of the effects of GLP-1(7-36)amide in normal, overnight cultured rat islets. It was found that GLP-1(7-36)amide stimulated insulin secretion, 45Ca2+-efflux, and 86Rb+-efflux from prelabelled islets. All these effects were abolished by omitting Na+ from the medium and replacing it with N-methyl-glucamine. This suggests that GLP-1(7-36)amide stimulates insulin secretion by depolarizing the β-cells by increasing their permeability to Na+. © 1991.

引用

页码：701 / 706

页数：6

共 12 条

[1]

AHREN B, 1990, PROGR BRAIN RES, V84, P209

[2] GLUCAGONLIKE PEPTIDE-I STIMULATES INSULIN GENE-EXPRESSION AND INCREASES CYCLIC-AMP LEVELS IN A RAT ISLET CELL-LINE [J].