PREPARATION AND REACTIONS OF CHIRAL PROPARGYLIC AMINES

被引：9

作者：

HAUSKE, JR

DORFF, P

JULIN, S

MARTINELLI, G

BUSSOLARI, J

机构：

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 26期

关键词：

D O I：

10.1016/S0040-4039(00)91995-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Exposure of chiral amino aldehydes (1) to dimethyl diazophosphonate (4) affords propargylic amines (2) of high optical purity. Chain extension of these intermediates is readily accomplished via hydrozirconation of the acetylene moiety and subsequent Ni(II) catalyzed Michael addition to a variety of Michael acceptors.

引用

页码：3715 / 3716

页数：2

共 24 条

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