INVESTIGATION OF POSTMORTEM FUNCTIONAL-CHANGES IN HUMAN CEREBRAL-ARTERIES

被引：19

作者：

ONOUE, H ^{[1
]}

KAITO, N ^{[1
]}

TOKUDOME, S ^{[1
]}

ABE, T ^{[1
]}

TASHIBU, K ^{[1
]}

NAGASHIMA, H ^{[1
]}

NAKAMURA, N ^{[1
]}

机构：

[1] TOKYO MED EXAMINERS OFF, TOKYO, JAPAN

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 1993年 / 13卷 / 02期

关键词：

BRADYKININ; ENDOTHELIUM-DEPENDENT VASODILATION; HUMAN CEREBRAL ARTERY; POSTMORTEM CHANGE; PROSTAGLANDIN-I2; SUBSTANCE-P;

D O I：

10.1038/jcbfm.1993.44

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study demonstrated the time-dependent changes in postmortem responses of isolated human middle cerebral artery strips to vasodilators. The relaxation induced by prostaglandin (PG) I2 or nitroglycerin remained stable for 24 h postmortem. In arterial strips precontracted with PGF2alpha, substance P and bradykinin both elicited relaxation that was almost completely abolished by removal of the endothelium. The endothelium-dependent response to both peptides was significantly degraded in strips obtained >12 h postmortem. These results indicate a selective functional or anatomical vulnerability of the vascular endothelium compared with that of the vasodilator mechanisms of the smooth muscle in the postmortem period. However, cerebral arteries isolated from human cadavers within 12 h postmortem should be adequate for studies of both smooth muscle and endothelial reactivity to vasodilators.

引用

页码：346 / 349

页数：4

共 24 条

[1] DETECTION OF ENDOTHELIUM IN CEREBRAL BLOOD-VESSELS [J].