INHIBITORY-ACTION OF AZELASTINE ON CYTOKINE PRODUCTION FROM HUMAN PERIPHERAL-BLOOD LEUKOCYTES IN-VITRO

被引：6

作者：

KONNO, S ^{[1
]}

ADACHI, M ^{[1
]}

ASANO, K ^{[1
]}

MATSUO, S ^{[1
]}

OKAMOTO, K ^{[1
]}

TAKAHASHI, T ^{[1
]}

机构：

[1] SHOWA UNIV, SCH MED, DEPT MED BIOL, SHINAGAWA KU, TOKYO 142, JAPAN

来源：

LIFE SCIENCES | 1993年 / 53卷 / 13期

关键词：

D O I：

10.1016/0024-3205(93)90264-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Effects of azelastine (AZ) on human peripheral blood leukocytes (PBL) in culture were examined. Addition of 10.0 mug/ml of AZ resulted in a marked inhibition of PBL blastic activity, but lower concentrations (1.0 and 0.5 mug/ml) had no demonstrable suppressive effects on the activation. Interleukin (IL)-2, IL-3 and IL-4 production from PBL in response to Concanavalin A stimulation was also strongly suppressed when the cells were cultured in the presence of AZ. This suppression was observed even when lower concentrations (1.0 and 0.5 mug/ml) of AZ were added to cell cultures.

引用

页码：PL201 / PL206

页数：6

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