THE FUNCTIONAL-EFFECTS OF GADOLINIUM-DTPA ON THE ISOLATED PERFUSED RAT-KIDNEY

被引：7

作者：

BROWN, PWG ^{[1
]}

HAYLOR, JL ^{[1
]}

MORCOS, SK ^{[1
]}

ELNAHAS, AM ^{[1
]}

机构：

[1] NO GEN HOSP,NHS TRUST,DEPT RADIOL,HERRIES RD,SHEFFIELD S5 7AU,S YORKSHIRE,ENGLAND

来源：

EUROPEAN JOURNAL OF RADIOLOGY | 1993年 / 16卷 / 02期

关键词：

CONTRAST MEDIA; GADOLINIUM; EFFECT ON KIDNEY; EXPERIMENTAL STUDY; KIDNEY;

D O I：

10.1016/0720-048X(93)90002-5

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Clinical experience suggests that Gd-DTPA has no deleterious effect on renal function. We have evaluated the effects of a large dose (0.6 ml/kg body weight) of this contrast agent on the function of the isolated perfused rat kidney. Gd-DTPA led to a mild, transient increase in glomerular filtration rate with no subsequent fall during the 30 minute observation period. However, Gd-DTPA induced an increase in renal vascular resistance (+10%, P< 0.05) as a mild decrease in renal perfusate flow was observed during the experimental phase when compared to that of control kidneys. No significant effect was demonstrated on the fractional excretion of albumin or the fractional reabsorption of sodium. These data support, in an ex vivo experimental model, the clinical experience of the safety of this paramagnetic contrast agent in relation to renal function.

引用

页码：85 / 89

页数：5

共 19 条

[1]

Niendorf, Dinger, Haustein, Cornelius, Al Hassan, Claub, Tolerance data of GD-DTPA: a review, Eur J Radiol, 13, pp. 15-20, (1991)

[2]

Frank, Choyke, Girton, Morrison, Diggs, Skinner, Gadopentetate dimeglumine clearance in renal insufficiency in rabbits, Invest Radiol, 25, pp. 1212-1216, (1990)

[3]

Tervahartiala, Contrast media induced renal tubular vacuolization after dehydration. A light and electron microscopic study in rats, Invest Radiol, 27, pp. 114-118, (1992)

[4]

Berns, Nephrotoxicity of contrast media, Kidney Int, 36, pp. 730-740, (1989)

[5]

Dawson, Trewhella, Intravascular contrast agents and renal failure, Clin Radiol, 41, pp. 373-375, (1990)

[6]

Dawson, Contrast agent nephrotoxicity — an appraisal, Br J Radiol, 58, pp. 121-124, (1985)

[7]

El Sayed, Haylor, El Nahas, Salzano, Morcos, Haemodynamic effects of water soluble contrast media on the isolated perfused rat kidney, Br J Radiol, 64, pp. 435-439, (1991)

[8]

Brown, Haylor, El Nahas, Morcos, A comparison of the functional effects of diatrizoate, ioxaglate and iotrolan on the isolated perfused rat kidney (Abstr), Br J Radiol, 64, (1991)

[9]

El Sayed, Haylor, El Nahas, The differential effect of amino acids on the isolated perfused rat kidney, Clin Sci, 79, pp. 381-386, (1990)

[10]

Lowry, Roseborough, Farr, Randall, Protein measurement with folin phenol reagent, J Biol Chem, 193, pp. 265-275, (1951)

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