SYNTHESIS OF NOVEL 2,7-DISUBSTITUTED-3-AMINO-9-TRIFLUOROMETHYL-4-OXO-4H-PYRIDO-[3',2'/4,5]-FURO-[3,2-D]-(1,3)-PYRIMIDINES

被引：10

作者：

NARSAIAH, B ^{[1
]}

SIVAPRASAD, A ^{[1
]}

VENKATARATNAM, RV ^{[1
]}

机构：

[1] INDIAN INST CHEM TECHNOL,HYDERABAD 500007,ANDHRA PRADESH,INDIA

来源：

JOURNAL OF FLUORINE CHEMISTRY | 1994年 / 69卷 / 02期

关键词：

SYNTHESIS; SUBSTITUTED PYRIDO FUROPYRIMIDINES; SUBSTITUTED PYRIDONES; SUBSTITUTED FUROPYRIDINES; NMR SPECTROSCOPY; IR SPECTROSCOPY; MASS SPECTROMETRY;

D O I：

10.1016/0022-1139(94)03079-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Synthesis of novel 2,7-disubstituted-3-amino-9-trifluoromethyl-4-oxo-4H-pyrido- [3',2':4,5]-furo[3,2-d]-(1,3)-pyramidines (5) from 3-cyano-4-trifluoromethyl-6-substituted 2(1H)-pyridones (1) via a series of new intermediates such as 2-O-ethylacetoxy-3-cyano-4-trifluoromethyl-6-substituted pyridines (2), 2-carbethoxy-3-amino-4-trifluoromethyl-6- furo-[2,3-b]-pyridines (3) and 2-carbohydrazide-3-amino-4-trifluoromethyl-6-substituted furo-[2, 3-b]-pyridines (4) have be en described.

引用

页码：139 / 143

页数：5

共 6 条

[1]

HASAN KM, 1990, PHOSPHORUS SULFUR SI, V47, P181

[2] AN IMPROVED SYNTHETIC ROUTE TO TRIFLUOROMETHYL-6-SUBSTITUTED-2(1H)-PYRIDONES [J].

NARSAIAH, B ;

SIVAPRASAD, A ;

VENKATARATNAM, RV .

ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 1993, 25 (01) :116-117

[3] A NOVEL SYNTHETIC ROUTE TO 2-AMINO-3-CYANO-4-TRIFLUOROMETHYL-6-SUBSTITUTED PYRIDINES [J].

NARSAIAH, B ;

SIVAPRASAD, A ;

VENKATARATNAM, RV .

JOURNAL OF FLUORINE CHEMISTRY, 1994, 67 (01) :87-90

[4]

Schaefer J.P., 1967, ORG REACT, V15, P1

[5]

Taylor E. C., 1970, ADV ORG CHEM

[6]

Von Gewald K., 1976, J PRAKT CHEM, V318, P313

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