SEROTONIN INHIBITS INDUCTION OF LONG-TERM POTENTIATION AT COMMISSURAL SYNAPSES IN HIPPOCAMPUS

被引：39

作者：

VILLANI, F ^{[1
]}

JOHNSTON, D ^{[1
]}

机构：

[1] BAYLOR COLL MED,DIV NEUROSCI,HOUSTON,TX 77030

来源：

BRAIN RESEARCH | 1993年 / 606卷 / 02期

关键词：

SEROTONIN; LONG-TERM POTENTIATION; HIPPOCAMPUS; NEUROMODULATION; SYNAPTIC TRANSMISSION; PLASTICITY;

D O I：

10.1016/0006-8993(93)90998-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study tests the effect of serotonin (5-HT) (1 muM) on the induction of long-term potentiation (LTP) at the commissural/associational (C/A)-CA3 synapse. The C/A input to CA3 was measured by field potentials in rat hippocampal slices. At the concentration used 5-HT had little or no effect on synaptic transmission, but suppressed the induction of LTP. Similar results were observed in normal saline and in saline containing picrotoxin (10 muM) and bicuculline (10 muM) to block GABA(A) inhibition. Perfusion with methysergide (I AM), a 5-HT antagonist, had no effect on synaptic transmission, but partially blocked the effect of 5-HT on LTP. The block of LTP by 5-HT could be overcome by using a higher intensity of stimulation suggesting that 5-HT might hyperpolarize the postsynaptic neurons to inhibit LTP induction. We conclude that the activation of serotonergic receptors inhibits the induction of LTP at the C/A-CA3 synapse.

引用

页码：304 / 308

页数：5

共 29 条

[1] PHARMACOLOGICALLY DISTINCT ACTIONS OF SEROTONIN ON SINGLE PYRAMIDAL NEURONS OF THE RAT HIPPOCAMPUS RECORDED INVITRO [J].