CANINE-DISTEMPER EPIZOOTIC IN LIONS, TIGERS, AND LEOPARDS IN NORTH-AMERICA

被引：194

作者：

APPEL, MJG

YATES, RA

FOLEY, GL

BERNSTEIN, JJ

SANTINELLI, S

SPELMAN, LH

MILLER, LD

ARP, LH

ANDERSON, M

BARR, M

PEARCEKELLING, S

SUMMERS, BA

机构：

[1] James A. Baker Institute for Animal Health, Cornell University, Ithaca

[2] Departments of Microbiology, Immunology and Parasitology, Cornell University, Ithaca

[3] Pathology (Pearce-Kelling, Summers), College of Veterinary Medicine, Cornell University, Ithaca

[4] Wildlife Way-station, Angeles National Forest, San Fernando, CA 91342

[5] Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801, 2814 VMBSB

[6] Ber-Mar Pet Hospital, Inglewood, CA 90301

[7] College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27695

[8] Department of Veterinary Pathology, Iowa State University, Ames, IA 50011-1250

[9] Hoffmann La Roche, Nutley, NJ 07110-1199

[10] Diagnostic Laboratory, College of Veterinary Medicine, University of California, Davis

来源：

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION | 1994年 / 6卷 / 03期

关键词：

D O I：

10.1177/104063879400600301

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Canine distemper virus (CDV) infection occurred in captive leopards (Panthera pardus), tigers (Panthera tigris), lions (Panthera leo), and a jaguar (Panthera onca) in 1991 and 1992. An epizootic affected all 4 types of cats at the Wildlife Waystation, San Fernando, California, with 17 mortalities. CDV-infected raccoons were thought to be the source of infection in these cats. Two black leopards died at the Naibi Zoo, Coal Valley, Illinois, and 2 tigers died at the Shambala Preserve, Acton, California. Initial clinical signs were anorexia with gastrointestinal and/or respiratory disease followed by seizures. Canine distemper virus was isolated from 3 leopards, 3 tigers, and 3 lions that died or were euthanized when moribund. Monoclonal antibody testing identified the virus isolates as CDV. Gross and histopathologic findings were similar to those found in canids with distemper with a few exceptions. There were fewer lesions in the brain, and there was a pronounced type 2 cell proliferation in the lung, with inclusion bodies and CDV antigen demonstrated by immunohistology. Neutralizing antibody to CDV was found in high titers in serum from most animals but was absent or was found only in low titers in some cats that succumbed after CDV infection. There was a marked difference in neutralizing antibody titers when tests were done with different strains of CDV.

引用

页码：277 / 288

页数：12

共 32 条

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