CIRCULATING INTERLEUKIN-6 RECEPTOR IN PATIENTS WITH SEPSIS SYNDROME

被引：70

作者：

FRIELING, JTM

VANDEUREN, M

WIJDENES, J

VANDERMEER, JWM

CLEMENT, C

VANDERLINDEN, CJ

SAUERWEIN, RW

机构：

[1] UNIV NIJMEGEN HOSP,DEPT INTERNAL MED,6500 HB NIJMEGEN,NETHERLANDS

[2] UNIV NIJMEGEN HOSP,DEPT MED MICROBIOL,6500 HB NIJMEGEN,NETHERLANDS

[3] INNOTHERAPIE LABS,BESANCON,FRANCE

来源：

JOURNAL OF INFECTIOUS DISEASES | 1995年 / 171卷 / 02期

关键词：

D O I：

10.1093/infdis/171.2.469

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Concentrations of interleukin (IL)-6, soluble IL-6 receptor (sIL-6R), and soluble tumor necrosis factor receptor (sTNFR) p55 and p75 were measured in 25 patients with sepsis syndrome, Sequential blood samples were drawn from patients during a 7-h period. IL-6 concentrations were 34-763,000 pg/mL; they were higher in nonsurvivors than survivors, but the difference was not statistically significant. In septic patients, the median sIL-6R concentration was significantly lower than in 19 healthy volunteers (43 vs. 80 ng/mL), sIL-6R concentrations in survivors were not significantly different than those in nonsurvivors. There was a negative correlation between IL-6 and sIL-6R in septic patients (r = -.72). In patients with moderately impaired renal function, sIL-6R levels were not affected, but the concentrations of sTNFRs were significantly higher.

引用

页码：469 / 472

页数：4

共 16 条

[1] Honda M., Yamamoto S., Cheng M., Et al., Human soluble 1l-6 receptor: Its detection and enhanced release by hiv infection, J Immunol, 148, pp. 2175-2180, (1992)
[2] Van Zee K.J., Kohno T., Fischer E., Rock C.S., Moldawer L.L., Lowry S.F., Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor-alpha in vitro and in vivo, Proc Natl Acad Sci USA, 89, pp. 4845-4849, (1992)
[3] Aderka D., Engelmann H., Maor Y., Brakebusch C., Wallach D., Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors, J Exp Med, 175, pp. 323-329, (1992)
[4] Mackiewicz A., Schooltink H., Heinrich P., Rose-John S., Complex of soluble human il-6-receptor/il-6 up-regulates expression ofacute-phase proteins, J Immunol, 149, pp. 2021-2027, (1992)
[5] Gaillard J.P., Bataille R., Brailly H., Et al., Increased and highly stable levels of functional soluble interleukin-6 receptor in sera of patients with monoclonal gammopathy, Eur J Immunol, 23, pp. 820-824, (1993)
[6] Frieling J., Sauerwein R., Wijdenes J., Hendriks T., Van Der Linden C., Soluble interleukin-6 receptor in biological fluids from human origin, Cytokine, 6, pp. 376-381, (1994)
[7] Damas P., Ledoux D., Nys M., Et al., Cytokine serum level during severe sepsis in human 1l-6 as a marker of severity, Ann Surg, 215, pp. 356-362, (1992)
[8] Bone R.C., Sepsis, the sepsis syndrome, multiorgan failure: A plea for comparable definitions, Ann Intern Med, 1, 15, pp. 332-333, (1991)
[9] Van Deuren M., Vander Ven-Jongekrijg J., Demacker P., Et al., Differential expression of proinflammatory cytokines and their inhibitors during the course of meningococcal infections, J Infect Dis, 169, pp. 157-161, (1994)
[10] Breen E.C., Rezai A.R., Nakajima K., Et al., Infection with hiv is associated with elevated il-6 levels and production, J Immunol, 144, pp. 480-484, (1990)

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