PREPARATION AND ANTIMYCOTIC PROPERTIES OF DERIVATIVES OF 1-PHENETHYLIMIDAZOLE

The synthesis of a large number of β-substituted 1-phenethylimidazoles is described. Many appropriately N-substituted 1-(β-aminophenethyl)imidazoles and cyclic ketals derived from 2-(1-imidazolyl)acetophenones were quite active against dermatophytes. However, 1-(β-benzyloxyphenethyl)imidazoles displayed potent, broad-spectrum activity, not only against dermatophytes but also against, yeast cells (Candida albicans) and gram-positive bacteria. © 1969, American Chemical Society. All rights reserved.