ACTIVATION OF PLASMINOGEN BY HUMAN PLASMA KALLIKREIN

被引：213

作者：

COLMAN, RW

机构：

[1] Department of Medicine, Harvard Medical School Boston.

[2] Department of Medicine, Massachusetts General Hospital, Boston

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 35卷 / 02期

关键词：

D O I：

10.1016/0006-291X(69)90278-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Purified human plasma kallikrein converts human plasminogen to plasmin. When plasminogen is present in excess, the yield of plasmin is proportional to the concentration of kallikrein with a molar ratio of the plasmin to kallikrein of 1.20. Addition of increasing amounts of plasminogen results in a maximum yield of plasmin equivalent to 1.19 moles/mole kallikrein. These data suggest the formation of a stoichiometric equimolar complex of plasmin and kallikrein in the course of the activation of plasminogen by kallikrein. Hageman factor activation of fibrinolysis appears to be mediated by kallikrein-catalyzed formation of plasmin from plasminogen. © 1969.

引用

页码：273 / &

共 18 条

[1]

ALKJAERSIG N, 1958, J BIOL CHEM, V233, P86

[2]

ALKJAERSIG N, 1959, J LAB CLIN MED, V64, P145

[3]

COLMAN RF, IN PRESS

[4] STUDIES ON PREKALLIKREIN (KALLIKREINOGEN)-KALLIKREIN ENZYME SYSTEM OF HUMAN PLASMA.I. ISOLATION AND PURIFICATION OF PLASMA KALLIKREINS [J].