EFFECT OF EXPERIMENTAL DIABETES AND INSULIN ON PHOSPHATIDYL-INOSITOL SYNTHESIS IN RAT SCIATIC-NERVE

被引：44

作者：

HOTHERSALL, JS

MCLEAN, P

机构：

[1] Courtauld Institute of Biochemistry, The Middlesex Hospital Medical School, London

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 88卷 / 02期

关键词：

D O I：

10.1016/0006-291X(79)92073-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The rate of incorporation of [2-3H]myo-inositol into phosphatidylinositol was found to be significantly decreased in sciatic nerve from both alloxan and streptozotocin-diabetic rats. The rates of incorporation into phospholipid of tritiated serine and ethanolamine were unchanged while choline showed an upward trend in sciatic nerve from alloxan-diabetic rats. Insulin added in vitro significantly increased [2-3H]myo-inositol incorporation into phospholipids by normal rat sciatic nerve; only small changes were recorded with high concentrations of glucose, and galactose. The results are discussed in relation to the physiological functions of phosphatidylinositol and the role of free myo-inositol in the regulation of cellular processes. © 1979.

引用

页码：477 / 484

页数：8

共 33 条

[1] DISTRIBUTION AND PROPERTIES OF CDP-DIGLYCERIDE - INOSITOL TRANSFERASE FROM BRAIN [J].