DOES FASTING INTERVAL AFFECT THE GLUCOSE CHALLENGE TEST

被引：7

作者：

BERKUS, MD ^{[1
]}

STERN, MP ^{[1
]}

MITCHELL, BD ^{[1
]}

NEWTON, ER ^{[1
]}

LANGER, O ^{[1
]}

机构：

[1] UNIV TEXAS,HLTH SCI CTR,DEPT MED,SAN ANTONIO,TX 78284

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1990年 / 163卷 / 06期

关键词：

GESTATIONAL DIABETES; GLUCOSE SCREENING; FASTING INTERVAL; INSULIN; OBESITY;

D O I：

10.1016/0002-9378(90)90755-V

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The relationship between fasting interval and glucose screening was assessed in a prospective study of 153 non-diabetic pregnant patients undergoing a standard 50g glucose challenge test. An interval of less than 3 hours after the last meal was found to be associated with significantly greater insulin response as opposed to a fasting interval of more than 3 hours (121.3 pmol/I vs. 83.5 pmol/I, p < .001) and a greater insulin/glucose index (0.92 vs. 0.66, p < .001), with no difference in plasma glucose. Overall, obese patients had a higher glucose response than non-obese, but only higher insulin levels (107 pmol/I vs. 69 pmol/I, p < .001) and insulin/glucose index (0.79 vs. 0.59, p < .02) when the fasting interval was greater than 3 hours. Our data suggest that the fasting interval can influence insulin response during a glucose challenge test and the aberration in insulin secretion may effect screening results, especially in the high-risk gravida with glucose abnormality.

引用

页码：1812 / 1817

页数：6

共 15 条

[1] RELATIONSHIP BETWEEN OBESITY AND MAXIMAL INSULIN-STIMULATED GLUCOSE-UPTAKE INVIVO AND INVITRO IN PIMA-INDIANS [J].