THE ROLE OF THE CYTOKINES, INTERFERON-ALPHA AND TUMOR-NECROSIS-FACTOR IN THE HYPERTRIGLYCERIDEMIA AND WASTING OF AIDS

被引:72
作者
GRUNFELD, C [1 ]
FEINGOLD, KR [1 ]
机构
[1] UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143
关键词
ACQUIRED IMMUNODEFICIENCY SYNDROME; CYTOKINES; LIPIDS; CACHEXIA; INFECTION;
D O I
10.1093/jn/122.suppl_3.749
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The hypertriglyceridemia of infection is mediated by many of the cytokines that regulate the immune response, including the tumor necrosis factors, the interleukins and the interferons. In the acquired immunodeficiency syndrome (AIDS),4 hypertriglyceridemia is most likely due to increased circulating levels of interferon alpha. Both in AIDS and in animal models there is no direct association between the presence of hypertriglyceridemia and the syndrome of wasting. Rather, circulating lipoproteins may neutralize infectious organisms and therefore contribute to host defense.
引用
收藏
页码:749 / 753
页数:5
相关论文
共 40 条
  • [1] GROWING TUMORS INDUCE HYPERSENSITIVITY TO ENDOTOXIN AND TUMOR-NECROSIS-FACTOR
    BARTHOLEYNS, J
    FREUDENBERG, M
    GALANOS, C
    [J]. INFECTION AND IMMUNITY, 1987, 55 (09) : 2230 - 2233
  • [2] METABOLIC RESPONSE TO INFECTION
    BEISEL, WR
    [J]. ANNUAL REVIEW OF MEDICINE, 1975, 26 : 9 - 20
  • [3] CACHECTIN AND TUMOR-NECROSIS-FACTOR AS 2 SIDES OF THE SAME BIOLOGICAL COIN
    BEUTLER, B
    CERAMI, A
    [J]. NATURE, 1986, 320 (6063) : 584 - 588
  • [4] CERAMI A, 1985, IMMUNOL LETT, V11, P173, DOI 10.1016/0165-2478(85)90165-8
  • [5] PHYSIOLOGIC CONCENTRATIONS OF NORMAL HUMAN-PLASMA LIPOPROTEINS INHIBIT THE IMMORTALIZATION OF PERIPHERAL LYMPHOCYTES-B BY THE EPSTEIN-BARR VIRUS
    CHISARI, FV
    CURTISS, LK
    JENSEN, FC
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1981, 68 (02) : 329 - 336
  • [6] DWORKIN B, 1990, CLIN RES, V38, pA361
  • [7] DIET AFFECTS THE MECHANISMS BY WHICH TNF STIMULATES HEPATIC TRIGLYCERIDE PRODUCTION
    FEINGOLD, KR
    ADI, S
    STAPRANS, I
    MOSER, AH
    NEESE, R
    VERDIER, JA
    DOERRLER, W
    GRUNFELD, C
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (02): : E177 - E184
  • [8] EFFECT OF INTERLEUKIN-1 (IL-1) ON THYROID-HORMONE METABOLISM IN MICE - STIMULATION BY IL-1 OF IODOTHYRONINE 5'-DEIODINATING ACTIVITY (TYPE-I) IN THE LIVER
    FUJII, T
    SATO, K
    OZAWA, M
    KASONO, K
    IMAMURA, H
    KANAJI, Y
    TSUSHIMA, T
    SHIZUME, K
    [J]. ENDOCRINOLOGY, 1989, 124 (01) : 167 - 174
  • [9] ACTIVATION OF PROTEIN BREAKDOWN AND PROSTAGLANDIN-E2 PRODUCTION IN RAT SKELETAL-MUSCLE IN FEVER IS SIGNALED BY A MACROPHAGE PRODUCT DISTINCT FROM INTERLEUKIN-1 OR OTHER KNOWN MONOKINES
    GOLDBERG, AL
    KETTELHUT, IC
    FURUNO, K
    FAGAN, JM
    BARACOS, V
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1988, 81 (05) : 1378 - 1383
  • [10] GRUNFELD C, 1989, CANCER RES, V49, P2554