STRUCTURE OF A NOVEL PHOSPHOLIPASE-C INHIBITOR, VINAXANTHONE (RO-09-1450), PRODUCED BY PENICILLIUM-VINACEUM

被引：38

作者：

AOKI, M

ITEZONO, Y

SHIRAI, H

NAKAYAMA, N

SAKAI, A

TANAKA, Y

YAMAGUCHI, A

SHIMMA, N

YOKOSE, K

SETO, H

机构：

[1] NIPPON ROCHE RES CTR,KAMAKURA,KANAGAWA 247,JAPAN

[2] UNIV TOKYO,INST APPL MICROBIOL,BUNKYO KU,TOKYO 113,JAPAN

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 36期

关键词：

VINAXANTHONE; PENICILLIUM-VINACEUM GILMAN AND ABBOTT; PHOSPHOLIPASE-C INHIBITOR;

D O I：

10.1016/S0040-4039(00)92295-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Vinaxanthone is a novel phospholipase C inhibitor produced by Penicillium vinaceum Gilman and Abbott NR6815. Its structure (MW 576, C28H16O14) has been elucidated as a polycyclic xanthone with poly acidic functional groups based on various NMR studies including HMBC. COLOC, 2D-INADEQUATE and selective 1D-INADEQUATE.

引用

页码：4737 / 4740

页数：4