DIPYRIDAMOLE AFFECTS MYOCARDIAL ADENOSINE KINASE-ACTIVITY

被引：4

作者：

DEJONG, JW

KEIJZER, E

机构：

[1] Cardiochemical Laboratory, Thoraxcentre, Erasmus University Rotterdam

来源：

ARCHIVES INTERNATIONALES DE PHYSIOLOGIE DE BIOCHIMIE ET DE BIOPHYSIQUE | 1979年 / 87卷 / 03期

关键词：

D O I：

10.3109/13813457909070516

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adenosine kinase (EN 2.7.1.20) from rat and dog heart was purified until it was devoid of adenosine deaminase activity. A stimulation of adenosine kinase activity by dipyridamole (1) was observed when the enzyme was assayed under optimal conditions. At low substrate concentrations adenosine kinase was inhibited by the drug. It increased the Km for adenosine sevenfold. The effects of dipyridamole were Mg2+-dependent. The adenosine-sparing action of dipyridamole at low substrate concentrations is in keeping with the vasodilatory action of the drug. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：525 / 532

页数：8

共 20 条

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[2]

BAER HP, 1966, MOL PHARMACOL, V2, P67

[3]

de Jong J W, 1974, Hoppe Seylers Z Physiol Chem, V355, P1213

[4] PARTIAL-PURIFICATION AND PROPERTIES OF RAT-HEART ADENOSINE KINASE [J].