Vitronectin and its receptors

被引:357
作者
Habermann, Brunhilde Felding [1 ,2 ]
Cheresh, David A. [3 ]
机构
[1] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Comm Vasc Biol SBR8, La Jolla, CA 92037 USA
[3] Scripps Res Inst, Dept Immunol IMM13, La Jolla, CA 92037 USA
关键词
D O I
10.1016/0955-0674(93)90036-P
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The extracellular matrix protein vitronectin is recognized as an adhesive substrate by cells expressing at least one of four known vitronectin receptors: integrins alpha v beta 1, alpha v beta 3, alpha v beta 5 or alpha llb beta 3. Cell interaction with vitronectin may induce spreading and migration and have an effect on cell growth and differentiation in specific processes, such as tumor growth and metastasis, wound healing, bone resorption and viral infection.
引用
收藏
页码:864 / 868
页数:5
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