NATURAL-KILLER ACTIVITY AND SERUM IMMUNOSUPPRESSIVE ACIDIC PROTEIN-LEVELS IN ESOPHAGEAL AND GASTRIC CANCERS

被引：34

作者：

OKA, M

MITSUNAGA, H

HAZAMA, S

YOSHINO, S

SUZUKI, T

机构：

[1] The Second Department of Surgery, Yamaguchi University School of Medicine, Ube Yamaguchi, 755

来源：

SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY | 1993年 / 23卷 / 08期

关键词：

ESOPHAGEAL CARCINOMA; GASTRIC CARCINOMA; NATURAL KILLER CELL; IMMUNOSUPPRESSIVE ACIDIC PROTEIN;

D O I：

10.1007/BF00311703

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The natural killer (NK) activity of peripheral blood mononuclear cells and serum immunosuppressive acidic protein (IAP) levels were examined in patients with esophageal or gastric cancer, before and after surgery. Patients with stage IV esophageal or stage IV gastric cancer had significantly lower NK activity (39.5 +/- 14.8% and 37 +/- 11.6%, respectively), and also higher serum IAP levels (778 +/- 264 mug/mL and 633 +/-156 mug/mL, respectively), than the corresponding control values (50 +/- 5.6% and 375 +/- 26 mug/mL, respectively). Patients with esophageal or gastric cancer who underwent curative resection had high NK activity (54.8 +/- 11.6% and 54.8 +/-8.0%, respectively), and low IAP levels (471 +/- 116 mug/mL and 490 +/- 42 mug/mL, respectively), compared with those who underwent non-curative resection. Patients who underwent non-curative resection had lower NK activity and higher serum IAP levels than those who underwent curative resection, even 1 month after surgery. Mononuclear cells in the regional lymph nodes and tumor specimens showed significantly lower NK activity than those in the peripheral blood and spleen. Thus, NK activity and the IAP level reflected the immunocompetence, clinical course, and surgical curability of those patients. NK cells appeared not to have any significant antitumor activity in the regional lymph nodes or in the tumor itself, although they were still active in the peripheral blood.

引用

页码：669 / 674

页数：6

共 16 条

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