A GENETIC-LOCUS OF ENTEROCYTE EFFACEMENT CONSERVED AMONG DIVERSE ENTEROBACTERIAL PATHOGENS

被引：1009

作者：

MCDANIEL, TK

JARVIS, KG

DONNENBERG, MS

KAPER, JB

机构：

[1] UNIV MARYLAND, SCH MED, DEPT MED, CTR VACCINE DEV, BALTIMORE, MD 21201 USA

[2] UNIV MARYLAND, SCH MED, GRAD PROGRAM MOLEC & CELL BIOL, BALTIMORE, MD 21201 USA

[3] UNIV MARYLAND, SCH MED, DEPT VET AFFAIRS MED CTR, MED SERV, BALTIMORE, MD 21201 USA

[4] UNIV MARYLAND, SCH MED, DEPT MED, DIV INFECT DIS, BALTIMORE, MD 21201 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 05期

关键词：

BACTERIAL PATHOGENESIS; EPITHELIAL CELLS; ATTACHING AND EFFACING LESIONS;

D O I：

10.1073/pnas.92.5.1664

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli O157:H7 are intestinal pathogens that profoundly damage the microvilli and subapical cytoskeleton of epithelial cells. Here we report finding in EPEC a 35-kbp locus containing several regions implicated in formation of these lesions. DNA probes throughout this locus hybridize to E. coli O157:H7 and other pathogens of three genera that cause similar lesions but do not hybridize to avirulent members of the same species. The EPEC locus and a different virulence locus of uropathogenic E. coli insert into the E. coli chromosome at the identical site and share highly similar sequences near the point of insertion.

引用

页码：1664 / 1668

页数：5

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