3BETA-HYDROXY-24-NORCHOL-5-EN-23-OIC ACID - A NEW INHIBITOR OF DELTA24-STEROL REDUCTASE ENZYME SYSTEM(S) IN TOBACCO HORNWORM MANDUCA SEXTA (JOHANNSON)

被引：13

作者：

SVOBODA, JA

THOMPSON, MJ

ROBBINS, WE

机构：

[1] Insect Physiology Laboratory, Entomology Research Division, Agricultural Research Service, Beltsville

来源：

STEROIDS | 1968年 / 12卷 / 05期

关键词：

D O I：

10.1016/S0039-128X(68)80033-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A commercial sample of β-sitosterol contained impurities that inhibited the conversion of β-sitosterol to cholesterol at the terminal step-the conversion of desmosterol to cholesterol-in the tobacco hornworm. The compounds responsible for this biological activity were isolated and shown to be 3β-hydroxy-24-norchol-5-en-23-oic acid and 3β-hydroxy-23,24-dinorchol-5-en-22-oic acid. The 23-carbon acid is the most active component, being several times more active than the 22-carbon acid as an inhibitor of Δ24-sterol reductase in vivo. The synthesis of 3β-hydroxy-24-norchol-5-en-23-oic acid is described. © 1968.

引用

页码：559 / &

共 8 条

[1]

BEHER WT, 1962, P SOC EXP BIOL MED, V109, P863, DOI 10.3181/00379727-109-27360

[2]

KUCERA J, 1958, COLLECT CZECH CHEM C, V23, P116

[3]

SVOBODA J. A., 1967, LIFE SCI, V6, P395, DOI 10.1016/0024-3205(67)90009-4

[4] CONVERSION OF BETA SITOSTEROL TO CHOLESTEROL BLOCKED IN AN INSECT BY HYPOCHOLESTEROLEMIC AGENTS [J].