SECRETORY ACTIVITY AND ONCOGENICITY OF A CELL LINE (MDCK) DERIVED FROM CANINE KIDNEY

被引:221
作者
LEIGHTON, J
BRADA, Z
ESTES, LW
JUSTH, G
机构
[1] Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA
关键词
D O I
10.1126/science.163.3866.472
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
A cell line (MDCK) of dog kidney origin grows on a glass surface as a mosaic of epithelium with many multicellular hemispherical vesicles. The cells lining the blisters actively secrete into the cyst cavities. Suspensions of these cells injected intravenously in the chick embryo produce brain metastases resembling adenocarcinoma.
引用
收藏
页码:472 / &
相关论文
共 2 条
  • [1] GAUSH CR, 1966, P SOC EXP BIOL MED, V122, P931
  • [2] LEIGHTON J, 1964, 79 PUBL HEALTH REP, P642